Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of IkappaBalpha and its mutants on NF-kappaB and p53 signaling pathways.

World journal of gastroenterology - 7 Nov 2006

Li Xian, Xing Da, Wang Ju, Zhu De-Bin, Zhang Lan, Chen Xiao-Jia, Sun Fen-Yong, Hong An

Abstract excerpt

AIM: To study the effects of IkappaBalpha and its mutants (IkappaBalphaM, IkappaBalpha243N, IkappaBalphaM244C) on NF-kappaB, p53 and their downstream target genes. The relationship of NF-kappaB, p53, and IkappaBalpha was further discussed. METHODS: pECFP-IkappaBalpha, pECFP-IkappaBalphaM (amino acides 1-317, Ser32, 36A), pECFP-IkappaBalpha243N (amino acides 1-243), pECFP-IkappaBalpha244C (amino acides 244-317),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Fluorescent Dyes
Share to I-kappa B Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Luminescent Proteins

Share to NF-kappa B

Share to NF-KappaB Inhibitor alpha

Share to Tumor Cells, Cultured

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 17075980
DOI: 10.3748/wjg.v12.i41.6658
PMCID: PMC4125672

Genes

CFP
TNF
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of IkappaBalpha and its mutants on NF-kappaB and p53 signaling pathways.PMID 17075980Read ↗

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.Semantic proximity Read ↗

Adenovirus-mediated overexpression of novel mutated IkappaBalpha inhibits nuclear factor kappaB activation in endothelial cells.Semantic proximity Read ↗

Suppression of p65 phosphorylation coincides with inhibition of IkappaBalpha polyubiquitination and degradation.Semantic proximity Read ↗

Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate.Semantic proximity Read ↗

IKKα mediates UVB-induced cell apoptosis by regulating p53 pathway activationSemantic proximity Read ↗

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation.Semantic proximity Read ↗

[Enhancement of HepG2 cell radiosensitivity by mutant IkappaBalpha gene transfection].Semantic proximity Read ↗

p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.Semantic proximity Read ↗

Mutated IkappaBalpha represses proliferation of immortalized neural progenitor cells and prevents their apoptosis after oxygen-glucose deprivation.Semantic proximity Read ↗

IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.Semantic proximity Read ↗

Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation.Semantic proximity Read ↗

Characterization of NFkappaB activation by detection of green fluorescent protein-tagged IkappaB degradation in living cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.