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Article

Adenovirus-mediated overexpression of novel mutated IkappaBalpha inhibits nuclear factor kappaB activation in endothelial cells.

Chinese medical journal - 5 Sept 2005

Zhou Lin-fu, Yin Kai-sheng, Zhu Zi-lu, Zhu Yi, Yao Xin, Mao Hui, Xie Wei-ping, Huang Mao

Abstract excerpt

BACKGROUND: Nuclear factor kappaB (NF-kappaB) overactivation, requiring phosphorylation and degradation of its inhibitor IkappaBalpha, is the basis for chronicity of airway inflammation in asthma. Based on our previous plasmid pShuttle-IkappaBalpha, carrying an IkappaBalpha gene from human placenta, we optimized a novel IkappaBalpha mutant (IkappaBalphaM) gene, constructed and characterized its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16157044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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