Article
Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster.
Molecular and cellular biology - 1 Jan 2007
Ing Bryant, Shteiman-Kotler Alina, Castelli MaryLisa, Henry Pauline, Pak Youngshil, Stewart Bryan, Boulianne Gabrielle L, Rotin Daniela
Abstract excerpt
Muscle synaptogenesis in Drosophila melanogaster requires endocytosis of Commissureless (Comm), a binding partner for the ubiquitin ligase dNedd4. We investigated whether dNedd4 and ubiquitination mediate this process. Here we show that Comm is expressed in intracellular vesicles in the muscle, whereas Comm bearing mutations in the two PY motifs (L/PPXY) responsible for dNedd4 binding [Comm(2PY-->AY)], or bearing...
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