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Article

Commissureless endocytosis is correlated with initiation of neuromuscular synaptogenesis.

Development (Cambridge, England) - 1 Oct 1998

Wolf B, Seeger M A, Chiba A

Abstract excerpt

We show that the Commissureless (COMM) transmembrane protein is required at neuromuscular synaptogenesis. All muscles in the Drosophila embryo express COMM during the period of motoneuron-muscle interaction. It is endocytosed into muscles before synaptogenesis. In comm loss-of-function mutants, motoneuron growth cones fail to initiate synaptogenesis at target muscles. This stall phenotype is rescued by supplying...

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PMID: 9729493
DOI: 10.1242/dev.125.19.3853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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