Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of IRF1 and IRF2 transcription factors in leukaemogenesis.

Current gene therapy - 1 Oct 2006

Choo Ailyn, Palladinetti Patricia, Passioura Toby, Shen Sylvie, Lock Richard, Symonds Geoff, Dolnikov Alla

Abstract excerpt

Acute myeloid leukaemia (AML) is the most common form of leukaemia in adults. Although of the order of 75-85% of patients will achieve complete remission after induction chemotherapy, long-term survival is still relatively low. Despite the progress in the rational design of drugs in disorders such as chronic myeloid leukaemia, AML lacks a single specific pathogenomic event to act as a drug target. Interferon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Interferon Regulatory Factor-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid

Share to Models, Animal

Share to Phenotype

Share to ras Proteins

Share to Signal Transduction

Source

Identifiers

PMID: 17073600
DOI: 10.2174/156652306778520683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of IRF1 and IRF2 transcription factors in leukaemogenesis.PMID 17073600Read ↗

Roles of Interferon Regulatory Factors in Chronic Myeloid LeukemiaSemantic proximity Read ↗

Interferon regulatory factor 1 inactivation in human cancerSemantic proximity Read ↗

Interferon regulatory factor family of transcription factors and regulation of oncogenesis.Semantic proximity Read ↗

IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent inflammatory overactivation in acute myeloid leukemia (AML) cellsSemantic proximity Read ↗

Function and mechanism by which interferon regulatory factor-1 inhibits oncogenesisSemantic proximity Read ↗

Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell DevelopmentSemantic proximity Read ↗

IRF1 regulates self-renewal and stress responsiveness to support hematopoietic stem cell maintenanceSemantic proximity Read ↗

IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenanceSemantic proximity Read ↗

IRF8: Mechanism of Action and Health ImplicationsSemantic proximity Read ↗

Expression of the Interferon Regulatory Factor Family and Its Prognostic Value in Acute Myeloid LeukemiaSemantic proximity Read ↗

Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.Semantic proximity Read ↗

Structure and Regulation of the Human Interferon Regulatory Factor 1 (IRF-1) and IRF-2 Genes: Implications for a Gene Network in the Interferon SystemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.