Article
Antitumorigenic effects of a mutant of the heparin affin regulatory peptide on the U87 MG glioblastoma cell line.
International journal of cancer - 1 Sept 2010
Dos Santos Célia, Karaky Racha, Renoir Dominique, Hamma-Kourbali Yamina, Albanese Patricia, Gobbo Emilie, Griscelli Frank, Opolon Paule, Dalle Sophie, Perricaudet Michel, Courty José, Delbé Jean
Abstract excerpt
Glioblastoma is the most common primary brain tumor in human adults. Since existing treatments are not effective enough, novel therapeutic targets must be sought. The heparin-binding growth factor, heparin affin regulatory peptide (HARP), also known as pleiotrophin (PTN), could potentially represent such a target. We have previously shown that a mutant protein, HARPDelta111-136, which lacks HARP's C-terminal 26...
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