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Article

Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells.

Oncotarget - 6 Dec 2016

Zhang Lei, Laaniste Liisi, Jiang Yiwen, Alafuzoff Irina, Uhrbom Lene, Dimberg Anna

Abstract excerpt

Pleiotrophin (PTN) augments tumor growth by increasing proliferation of tumor cells and promoting vascular abnormalization, but its role in early gliomagenesis has not been evaluated. Through analysis of publically available datasets, we demonstrate that increased PTN mRNA expression is associated with amplification of chromosome 7, identified as one of the earliest steps in glioblastoma development. To elucidate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27806344
DOI: 10.18632/oncotarget.12983
PMCID: PMC5348327

Genes

PTN
PDGFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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