Article
Inhibitory effect of pisosterol on human glioblastoma cell lines with C-MYC amplification.
Journal of applied toxicology : JAT - 1 Aug 2011
Pereira Edmundo L R, Lima Patrícia D L, Khayat André S, Bahia Marcelo O, Bezerra Franciglauber S, Andrade-Neto Manoel, Montenegro Raquel C, Pessoa Cláudia, Costa-Lotufo Letícia V, Moraes Manoel O, Yoshioka France K N, Pinto Giovanny R, Burbano Rommel R
Abstract excerpt
Despite the remarkable progress in the characterization of the molecular pathogenesis of glioblastoma multiforme (GBM), these tumors remain incurable and, in most cases, refractory to aggressive cytotoxic treatments. We conducted a morphological and cytogenetic study in two GBM cell lines (U343 and AHOL1), before and after treatment with pisosterol (at 0.5, 1.0 and 1.8 µg ml⁻¹), a triterpene isolated from the...
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