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Differential Induction of Glioblastoma Migration and Growth by Two Forms of Pleiotrophin

21 May 2005

Abstract excerpt

Glioblastoma is the most common malignant brain tumor of adults and one of the most lethal cancers. The secreted growth factor pleiotrophin (PTN) promotes glioblastoma migration and proliferation, initiating its oncogenic activities through two cell surface receptors, the protein tyrosine phosphatase receptor zeta (PTPRZ1) and the anaplastic lymphoma kinase (ALK), respectively. Here, we report on the presence and...

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PMID: 15908427
DOI: 10.1074/jbc.m502614200

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