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Article

MHC class I antigen presentation and implications for developing a new generation of therapeutic vaccines

5 Mar 2014

Abstract excerpt

Major histocompatibility complex class I (MHC-I) presented peptide epitopes provide a 'window' into the changes occurring in a cell. Conventionally, these peptides are generated by proteolysis of endogenously synthesized proteins in the cytosol, loaded onto MHC-I molecules, and presented on the cell surface for surveillance by CD8(+) T cells. MHC-I restricted processing and presentation alerts the immune system...

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PMID: 24790732
DOI: 10.1177/2051013614525375

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