Article
Peptide mimics of a tumor antigen induce functional cytotoxic T cells.
Nature biotechnology - 1 Mar 1998
Apostolopoulos V, Lofthouse S A, Popovski V, Chelvanayagam G, Sandrin M S, McKenzie I F
Abstract excerpt
The ability to mimic peptide/peptide and/or peptide/carbohydrate structures may be important in generating cross-reactive antibodies for autoimmune and other diseases. We show that the peptide sequence DAHWESWL can mimic the conformation of the unrelated MUC1 peptide SAPDTRPAP(G). Mice immunized...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Neoplasm
- Epitopes
- Female
- HLA-A Antigens
- Humans
- Immunization
- Immunotherapy
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Inbred Strains