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Article

Human DNA replication initiation factors, ORC and MCM, associate with <i>oriP</i> of Epstein–Barr virus

21 Aug 2001

Abstract excerpt

The 165-kb chromosome of Epstein-Barr virus (EBV) is replicated by cellular enzymes only once per cell cycle in human cells that are latently infected. Here, we report that the human origin recognition complex, ORC, can be detected in association with an EBV replication origin, oriP, in cells by using antibodies against three different subunits of human ORC to precipitate crosslinked chromatin. Mcm2, a subunit of...

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PMID: 11517328
DOI: 10.1073/pnas.181347998

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Related research

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Human DNA replication initiation factors, ORC and MCM, associate with <i>oriP</i> of Epstein–Barr virusPMID 11517328Read ↗

Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virusSemantic proximity Read ↗

Epstein-Barr Nuclear Antigen 1 (EBNA1)-dependent Recruitment of Origin Recognition Complex (Orc) on oriP of Epstein-Barr Virus with Purified ProteinsSemantic proximity Read ↗

The BAH domain facilitates the ability of human Orc1 protein to activate replication origins in vivo.Semantic proximity Read ↗

Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein–Barr virusSemantic proximity Read ↗

Two subunits of human ORC are dispensable for DNA replication and proliferationSemantic proximity Read ↗

Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin.Semantic proximity Read ↗

The Amino Terminus of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Contains AT Hooks That Facilitate the Replication and Partitioning of Latent EBV Genomes by Tethering Them to Cellular ChromosomesSemantic proximity Read ↗

An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication.Semantic proximity Read ↗

The Epstein-Barr Virus Episome Maneuvers between Nuclear Chromatin Compartments during ReactivationSemantic proximity Read ↗

Cellular transcription factors recruit viral replication proteins to activate the Epstein–Barr virus origin of lytic DNA replication, oriLytSemantic proximity Read ↗

Maintenance of Epstein–Barr virus (EBV) <i>oriP</i> -based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1Semantic proximity Read ↗

Active transcription regulates ORC/MCM distribution whereas replication timing correlates with ORC density in human cellsSemantic proximity Read ↗

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