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Article

Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity.

Nature - 26 Oct 2006

Tarchini Basile, Duboule Denis, Kmita Marie

Abstract excerpt

The anterior to posterior (A-P) polarity of the tetrapod limb is determined by the confined expression of Sonic hedgehog (Shh) at the posterior margin of developing early limb buds, under the control of HOX proteins encoded by gene members of both the HoxA and HoxD clusters. Here, we use a set of partial deletions to show that only the last four Hox paralogy groups can elicit this response: that is, precisely...

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Identifiers

PMID: 17066034
DOI: 10.1038/nature05247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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