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Putative endogenous filovirus VP35-like protein potentially functions as an IFN antagonist but not a polymerase cofactor

17 Oct 2017

Abstract excerpt

It has been proposed that some non-retroviral RNA virus genes are integrated into vertebrate genomes. Endogenous filovirus-like elements (EFLs) have been discovered in some mammalian genomes. However, their potential roles in ebolavirus infection are unclear. A filovirus VP35-like element (mlEFL35) is found in the little brown bat (Myotis lucifugus) genome. Putative mlEFL35-derived protein (mlEFL35p) contains...

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PMID: 29040311
DOI: 10.1371/journal.pone.0186450

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