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Article

Spectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway.

The Journal of cell biology - 23 Oct 2006

Das Amlan, Base Christine, Dhulipala Srilakshmi, Dubreuil Ronald R

Abstract excerpt

Prevailing models place spectrin downstream of ankyrin in a pathway of assembly and function in polarized cells. We used a transgene rescue strategy in Drosophila melanogaster to test contributions of four specific functional sites in beta spectrin to its assembly and function. (1) Removal of the pleckstrin homology domain blocked polarized spectrin assembly in midgut epithelial cells and was usually lethal. (2)...

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Share to Ankyrins
Share to Cytoskeleton
Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17060500
DOI: 10.1083/jcb.200602095
PMCID: PMC2064573

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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