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Article

Spectrin tetramer formation is not required for viable development in Drosophila.

The Journal of biological chemistry - 9 Jan 2015

Khanna Mansi R, Mattie Floyd J, Browder Kristen C, Radyk Megan D, Crilly Stephanie E, Bakerink Katelyn J, Harper Sandra L, Speicher David W, Thomas Graham H

Abstract excerpt

The dominant paradigm for spectrin function is that (αβ)2-spectrin tetramers or higher order oligomers form membrane-associated two-dimensional networks in association with F-actin to reinforce the plasma membrane. Tetramerization is an essential event in such structures. We characterize the tetramerization interaction between α-spectrin and β-spectrins in Drosophila. Wild-type α-spectrin binds to both β- and...

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Source

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Identifiers

PMID: 25381248
DOI: 10.1074/jbc.M114.615427
PMCID: PMC4294495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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