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Article

Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia.

The Journal of cell biology - 23 Oct 2006

Mukhopadhyay Sudit S, Leung Kathryn S, Hicks M John, Hastings Philip J, Youssoufian Hagop, Plon Sharon E

Abstract excerpt

Cells from patients with Fanconi anemia (FA), an inherited disorder that includes bone marrow failure and cancer predisposition, have increased sensitivity to oxidative stress through an unknown mechanism. We demonstrate that the FA group G (FANCG) protein is found in mitochondria. Wild-type but...

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Source

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Identifiers

PMID: 17060495
DOI: 10.1083/jcb.200607061
PMCID: PMC2064564

Genes

PRDX3
FANCG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17060495-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia.PMID 17060495Read ↗

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