Article
Role of the S. typhimurium actin-binding protein SipA in bacterial internalization.
Science (New York, N.Y.) - 26 Mar 1999
Zhou D, Mooseker M S, Galán J E
Abstract excerpt
Entry of the bacterium Salmonella typhimurium into host cells requires membrane ruffling and rearrangement of the actin cytoskeleton. Here, it is shown that the bacterial protein SipA plays a critical role in this process. SipA binds directly to actin, decreases its critical concentration, and inhibits depolymerization of actin filaments. These activities result in the spatial localization and more pronounced...
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