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Article

Structure and Inhibition of a Quorum Sensing Target from Streptococcus pneumoniae

1 Oct 2006

Abstract excerpt

Streptococcus pneumoniae 5'-methylthioadenosine/S-adenosylhomocysteine hydrolase (MTAN) catalyzes the hydrolytic deadenylation of its substrates to form adenine and 5-methylthioribose or S-ribosylhomocysteine (SRH). MTAN is not found in mammals but is involved in bacterial quorum sensing. MTAN gene disruption affects the growth and pathogenicity of bacteria, making it a target for antibiotic design. Kinetic...

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PMID: 17059210
DOI: 10.1021/bi061184i

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