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Article

Characterization of S-adenosylhomocysteine/Methylthioadenosine nucleosidase on secretion of AI-2 and biofilm formation of Escherichia coli.

Microbial pathogenesis - 1 Jul 2017

Han Tian, Li Yanhua, Shan Qiuli, Liang Wenjing, Hao Weiwei, Li Yumei, Tan Xiaojun, Gu Jinsong

Abstract excerpt

S-adenosylhomocysteine/Methylthioadenosine nucleosidase (SAHN E.C.3.2.2.9) does not exist in mammalian cells but is essential for methyl recycling in numerous bacterial and protozoan species. Inhibition of this enzyme could limit synthesis of autoinducers of bacterial quorum sensing (QS), and hence, causes reduction in biofilm formation and may attenuate virulence. In this study, sahn deletion mutant of E. coli...

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PMID: 28487228
DOI: 10.1016/j.micpath.2017.05.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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