Article
Neutral proteinases of human mononuclear phagocytes. Cellular differentiation markedly alters cell phenotype for serine proteinases, metalloproteinases, and tissue inhibitor of metalloproteinases.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1991
Campbell E J, Cury J D, Shapiro S D, Goldberg G I, Welgus H G
Abstract excerpt
Mononuclear phagocytes have the capacity to directly participate in extracellular matrix turnover via secretion of neutral proteinases. We have studied the effects of in vivo and in vitro differentiation upon cellular content or secretion of a spectrum of neutral proteinases, along with a counter-regulatory metalloproteinase inhibitor (TIMP). We found 1) matrix-degradative serine proteinases (leukocyte elastase...
Topics
- Cell Differentiation
- Extracellular Matrix
- Glycoproteins
- Humans
- In Vitro Techniques
- Macrophages
- Metalloendopeptidases
- Monocytes
- Phagocytes
- Phenotype