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Article

Cytokine production by leukocytes of Papillon-Lefèvre syndrome patients in whole blood cultures.

Clinical oral investigations - 1 Apr 2012

Sadik Christian D, Noack Barbara, Schacher Beate, Pfeilschifter Josef, Mühl Heiko, Eickholz Peter

Abstract excerpt

Papillon-Lefèvre syndrome (PLS) is characterised by aggressively progressive periodontitis combined with palmo-plantar hyperkeratosis. It is caused by "loss of function" mutations in the cathepsin C gene. The hypothesis behind this study is that PLS patients' polymorphonuclear leukocytes (PMNs) produce more proinflammatory cytokines to compensate for their reduced capacity to neutralize leukotoxin and to...

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Source

Identifiers

PMID: 21380503
DOI: 10.1007/s00784-011-0532-0

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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