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Article

Abnormal PGE(2) regulation of monocyte TNF-alpha levels in trauma patients parallels development of a more macrophage-like phenotype.

Shock (Augusta, Ga.) - 1 Sept 2004

Laudanski Krzysztof, De Asit, Brouxhon Sabine, Kyrkanides Stephanos, Miller-Graziano Carol

Abstract excerpt

Some trauma patients' monocytes (MO) increase TNF-alpha levels concomitant to augmenting production of the TNF-alpha inhibitor prostaglandin E2 (PGE2), suggesting posttrauma MO insensitivity to PGE2 effects. This study assesses additional posttrauma MO PGE2 insensitivity effects on altering TNF-alpha form (membrane versus secreted), down-regulating MO receptor expression, and depressing MO APC function....

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Source

Identifiers

PMID: 15316388
DOI: 10.1097/01.shk.0000135289.62159.ad

Genes

APC
TNF
TLR4
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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