Biosynthesis and secretion of M- and Z-type alpha 1-proteinase inhibitor by human monocytes. Effect of inhibitors of glycosylation and of oligosaccharide processing on secretion and function.

doi:10.1515/bchm3.1990.371.1.231

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Article

Biosynthesis and secretion of M- and Z-type alpha 1-proteinase inhibitor by human monocytes. Effect of inhibitors of glycosylation and of oligosaccharide processing on secretion and function.

Biological chemistry Hoppe-Seyler - 1 Mar 1990

Gross V, vom Berg D, Kreuzkamp J, Ganter U, Bauer J, Würtemberger G, Schulz-Huotari C, Beeser H, Gerok W

Abstract excerpt

The biosynthesis and secretion of M-type and Z-type alpha 1-antitrypsin was studied in human monocytes. In monocytes of PiMM individuals alpha 1-antitrypsin represented 0.08% of the newly synthesized proteins and 0.44% of the secreted proteins. Two molecular forms of alpha 1-antitrypsin could be...

Topics

Alkaloids
Cells, Cultured
Glycosylation
Humans
In Vitro Techniques
Macromolecular Substances
Mannosidases
Monocytes
Pancreatic Elastase
Phenotype
Swainsonine
Tunicamycin
alpha 1-Antitrypsin
alpha 1-Antitrypsin Deficiency

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Identifiers

PMID: 2111144
DOI: 10.1515/bchm3.1990.371.1.231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2111144-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.