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Article

Defective monocyte costimulation for IFN-γ production in familial disseminated Mycobacterium avium complex infection: abnormal IL-12 regulation

1 Jul 1996

Abstract excerpt

We have described previously a family in which several members have disseminated Mycobacterium avium complex infection. PBMC from affected members produced abnormally low amounts of IFN-gamma upon stimulation with PHA. Using PHA-stimulated allogeneic cocultures of highly purified monocytes and T cells from familial patients and normal subjects, we have now demonstrated that familial patient monocytes are...

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Identifiers

PMID: 8683146
DOI: 10.4049/jimmunol.157.1.411

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Source receipt: pubmed, retrieved 7 Sept 2026.

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