Article
IL-2 receptor alpha(-/-) mice and the development of primary biliary cirrhosis.
Hepatology (Baltimore, Md.) - 1 Nov 2006
Wakabayashi Kanji, Lian Zhe-Xiong, Moritoki Yuki, Lan Ruth Y, Tsuneyama Koichi, Chuang Ya-Hui, Yang Guo-Xiang, Ridgway William, Ueno Yoshiyuki, Ansari Aftab A, Coppel Ross L, Mackay Ian R, Gershwin M Eric
Abstract excerpt
Recently, we identified a child born with a genetic deficiency of IL-2 receptor alpha (IL-2Ralpha, CD25) expression who had several clinical manifestations of primary biliary cirrhosis (PBC). In addition, there has been suggestive evidence in both patients with PBC and their first-degree relatives that a deficiency of regulatory T cells (Tregs) is an integral component for susceptibility to PBC. Based on these...
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