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Article

Upregulation of the tumor suppressor gene menin in hepatocellular carcinomas and its significance in fibrogenesis

20 Oct 2006

Abstract excerpt

The molecular mechanisms underlying the progression of cirrhosis toward hepatocellular carcinoma were investigated by a combination of DNA microarray analysis and literature data mining. By using a microarray screening of suppression subtractive hybridization cDNA libraries, we first analyzed genes differentially expressed in tumor and nontumor livers with cirrhosis from 15 patients with hepatocellular...

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PMID: 17058241
DOI: 10.1002/hep.21367

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