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Article

Dysregulated paired related homeobox 1 impacts on hepatocellular carcinoma phenotypes.

BMC cancer - 8 Sept 2021

Piorońska Weronika, Nwosu Zeribe Chike, Han Mei, Büttner Michael, Ebert Matthias Philip, Dooley Steven, Meyer Christoph

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death. Paired related homeobox 1 (PRRX1) is a transcription factor that regulates cell growth and differentiation, but its importance in HCC is unclear. METHODS: We examined the expression pattern of PRRX1 in nine microarray datasets of human HCC tumour samples (n > 1100) and analyzed its function in HCC cell lines. In addition, we...

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Share to Carcinoma, Hepatocellular
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Homeodomain Proteins

Share to Liver Neoplasms

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Share to Tumor Cells, Cultured

Source

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Identifiers

PMID: 34496784
DOI: 10.1186/s12885-021-08637-3
PMCID: PMC8424914

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