Article
Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease.
Journal of molecular medicine (Berlin, Germany) - 1 Dec 2006
Moehle Christoph, Ackermann Nikolaus, Langmann Thomas, Aslanidis Charalampos, Kel Alexander, Kel-Margoulis Olga, Schmitz-Madry Anna, Zahn Alexandra, Stremmel Wolfgang, Schmitz Gerd
Abstract excerpt
Loss of intestinal mucosa integrity is an important factor in the pathogenesis of inflammatory bowel disease (IBD). The aim of this study was to characterize expression changes and allelic variants of genes related to intestinal epithelial barrier function in this disease. Therefore, ileal and colonic mucosal biopsies from nonaffected regions of patients with ulcerative colitis (UC) and Crohn's disease (CD), as...
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