Functional consequences of NOD2/CARD15 mutations in Crohn disease.

Abstract excerpt

Crohn disease (CD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract. Its etiology remained obscure until recently, when, through an overwhelming body of research, the main theme of its origin became clear. CD develops in individuals who carry risk alleles for the disease that can cause a loss of physiological tolerance to commensal bacteria. As a consequence, immune responses develop...

Topics

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• Autoimmunity
• Crohn Disease
• NOD2 gene
• Intestinal Mucosa
• Mutation