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Article

Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation.

The EMBO journal - 20 Jan 2010

Lee Seong-Ok, Cho Kwangmin, Cho Sunglim, Kim Ilkwon, Oh Changhoon, Ahn Kwangseog

Abstract excerpt

The human cytomegalovirus glycoprotein US2 induces dislocation of MHC class I heavy chains from the endoplasmic reticulum (ER) into the cytosol and targets them for proteasomal degradation. Signal peptide peptidase (SPP) has been shown to be integral for US2-induced dislocation of MHC class I heavy chains although its mechanism of action remains poorly understood. Here, we show that knockdown of protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19942855
DOI: 10.1038/emboj.2009.359
PMCID: PMC2824452

Genes

CFTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation.PMID 19942855Read ↗

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