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Article

Human cytomegalovirus inhibits antigen presentation by a sequential multistep process.

1 Oct 1996

Abstract excerpt

The human cytomegalovirus (HCMV) genomic unique short (US) region encodes a family of homologous genes essential for the inhibition of major histocompatibility complex (MHC) class I-mediated antigen presentation during viral infection. Here we show that US3, the only immediate early (IE) gene within the US region, encodes an endoplasmic reticulum-resident glycoprotein that prevents intracellular transport of MHC...

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Identifiers

PMID: 8855296
DOI: 10.1073/pnas.93.20.10990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Human cytomegalovirus inhibits antigen presentation by a sequential multistep process.PMID 8855296Read ↗

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Human cytomegalovirus US3 modulates destruction of MHC class I moleculesSemantic proximity Read ↗

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The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the CytosolSemantic proximity Read ↗

Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.Semantic proximity Read ↗

Suppression of CD8+ T-cell recognition in the immediate-early phase of human cytomegalovirus infectionSemantic proximity Read ↗

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Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus ImmunoevasionSemantic proximity Read ↗

Predictive Analysis of Binding Affinity among Human Cytomegalovirus (HCMV) Proteins and Class-I Major Histocompatibility Complex (MHC-I) MoleculesSemantic proximity Read ↗

Amino acid composition of α1/α2 domains and cytoplasmic tail of MHC class I molecules determine their susceptibility to human cytomegalovirus US11‐mediated down‐regulationSemantic proximity Read ↗

The MHC Class I Homolog of Human Cytomegalovirus Is Resistant to Down-Regulation Mediated by the Unique Short Region Protein (US)2, US3, US6, and US11 Gene ProductsSemantic proximity Read ↗

Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2Semantic proximity Read ↗

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