Article
Genetic evolution of gp41 reveals a highly exclusive relationship between codons 36, 38 and 43 in gp41 under long-term enfuvirtide-containing salvage regimen.
AIDS (London, England) - 24 Oct 2006
Cabrera Cecilia, Marfil Silvia, García Elisabet, Martinez-Picado Javier, Bonjoch Anna, Bofill Margarita, Moreno Santiago, Ribera Esteban, Domingo Pere, Clotet Bonaventura, Ruiz Lidia
Abstract excerpt
OBJECTIVE: To analyse the genetic changes in the gp41 protein in HIV-infected patients with detectable plasma viraemia receiving a long-term salvage enfuvirtide regimen. METHODS: We studied 13 heavily antiretroviral-experienced patients receiving a salvage regimen containing enfuvirtide. Substitutions in gp41 were analysed by population-based sequencing at baseline and longitudinally after the initiation of...
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