Article
Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein.
Science (New York, N.Y.) - 20 Oct 2006
Goley Erin D, Ohkawa Taro, Mancuso Joel, Woodruff Jeffrey B, D'Alessio Joseph A, Cande W Zacheus, Volkman Loy E, Welch Matthew D
Abstract excerpt
Diverse bacterial and viral pathogens induce actin polymerization in the cytoplasm of host cells to facilitate infection. Here, we describe a pathogenic mechanism for promoting dynamic actin assembly in the nucleus to enable viral replication. The baculovirus Autographa californica multiple nucleopolyhedrovirus induced nuclear actin polymerization by translocating the host actin-nucleating Arp2/3 complex into the...
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