Article
Increase in sensitivity to soluble CD4 by primary HIV type 1 isolates after passage through C8166 cells: association with sequence differences in the first constant (C1) region of glycoprotein 120.
AIDS research and human retroviruses - 1 Mar 1995
Orloff S L, Bandea C I, Kennedy M S, Allaway G P, Maddon P J, McDougal J S
Abstract excerpt
Primary isolates of human immunodeficiency virus type 1 (HIV-1) were obtained by coculture of peripheral blood lymphocytes (PBLs) from HIV-1-infected people with PBLs from uninfected donors. These viral stocks tend to be resistant to neutralization/inactivation by soluble CD4 (sCD4). When these s...
Topics
- Amino Acid Sequence
- Antigens, CD
- CD4 Antigens
- Cell Line
- Cells, Cultured
- DNA, Viral
- Giant Cells
- HIV Envelope Protein gp120
- HIV Seropositivity
- HIV-1
- Humans
- Kinetics
- Lymphocytes
- Male
- Molecular Sequence Data
- Phenotype
- Polymerase Chain Reaction
- Proviruses