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Article

Epigenetic Gene Silencing Underlies C-Fiber Dysfunctions in Neuropathic Pain

31 Mar 2010

Abstract excerpt

Peripheral nerve injury causes neuropathic pain, which is characterized by the paradoxical sensations of positive and negative symptoms. Clinically, negative signs are frequently observed; however, their underlying molecular mechanisms are largely unknown. Dysfunction of C-fibers is assumed to underlie negative symptoms and is accompanied by long-lasting downregulation of Na(v)1.8 sodium channel and mu-opioid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20357131
DOI: 10.1523/jneurosci.5541-09.2010

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