Article
Staphylococcus aureus IsdB is a hemoglobin receptor required for heme iron utilization.
Journal of bacteriology - 1 Dec 2006
Torres Victor J, Pishchany Gleb, Humayun Munir, Schneewind Olaf, Skaar Eric P
Abstract excerpt
The pathogenesis of human infections caused by the gram-positive microbe Staphylococcus aureus has been previously shown to be reliant on the acquisition of iron from host hemoproteins. The iron-regulated surface determinant system (Isd) encodes a heme transport apparatus containing three cell wall-anchored proteins (IsdA, IsdB, and IsdH) that are exposed on the staphylococcal surface and hence have the potential...
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