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The human protein haptoglobin inhibits IsdH-mediated heme-sequestering by Staphylococcus aureus

9 Dec 2019

Abstract excerpt

Iron is an essential nutrient for all living organisms. To acquire iron, many pathogens have developed elaborate systems to steal it from their hosts. The iron acquisition system in the opportunistic pathogen Staphylococcus aureus comprises nine proteins, called iron-regulated surface determinants (Isds). The Isd components enable S. aureus to extract heme from hemoglobin (Hb), transport it into the bacterial...

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PMID: 31819010
DOI: 10.1074/jbc.ra119.011612

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