IsdB-dependent hemoglobin binding is required for acquisition of heme by Staphylococcus aureus.

Abstract excerpt

Staphylococcus aureus is a Gram-positive pathogen responsible for tremendous morbidity and mortality. As with most bacteria, S. aureus requires iron to cause disease, and it can acquire iron from host hemoglobin. The current model for staphylococcal hemoglobin-iron acquisition proposes that S. aureus binds hemoglobin through the surface-exposed hemoglobin receptor IsdB. IsdB removes heme from bound hemoglobin and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cation Transport Proteins
• Share to Gene Expression Regulation, Bacterial