Iron-regulated surface determinant B (IsdB) promotesStaphylococcus aureusadherence to and internalization by non-phagocytic human cells

Abstract excerpt

Staphylococcus aureus is a human pathogen that causes invasive and recurring infections. The ability to internalize into and persist within host cells is thought to contribute to infection. Here we report a novel role for the well-characterized iron-regulated surface determinant B (IsdB) protein which we have shown can promote adhesion of 293T, HeLa cells and platelets to immobilized bacteria independently of its...

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