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IsdA of Staphylococcus aureus is a broad spectrum, iron‐regulated adhesin

4 Feb 2004

Abstract excerpt

As an important facet of host-pathogen interaction, Staphylococcus aureus has the ability to adhere to human extracellular matrix (ECM) components via a range of surface proteins. Here we have shown that IsdA has broad-spectrum ligand-binding activity, including fibrinogen and fibronectin. Mapping studies revealed a distinct domain responsible for ligand binding. This domain is present in a number of...

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PMID: 14982642
DOI: 10.1111/j.1365-2958.2003.03938.x

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