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Article

Specificity for human hemoglobin enhances Staphylococcus aureus infection.

Cell host & microbe - 16 Dec 2010

Pishchany Gleb, McCoy Amanda L, Torres Victor J, Krause Jens C, Crowe James E, Fabry Mary E, Skaar Eric P

Abstract excerpt

Iron is required for bacterial proliferation, and Staphylococcus aureus steals this metal from host hemoglobin during invasive infections. This process involves hemoglobin binding to the cell wall of S. aureus, heme extraction, passage through the cell envelope, and degradation to release free iron. Herein, we demonstrate an enhanced ability of S. aureus to bind hemoglobin derived from humans as compared to other...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21147468
DOI: 10.1016/j.chom.2010.11.002
PMCID: PMC3032424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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