Article
Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses.
Human molecular genetics - 15 Nov 2006
Keen-Kim Dianne, Mathews Carol A, Reus Victor I, Lowe Thomas L, Herrera Luis Diego, Budman Cathy L, Gross-Tsur Varda, Pulver Ann E, Bruun Ruth D, Erenberg Gerald, Naarden Allan, Sabatti Chiara, Freimer Nelson B
Abstract excerpt
Rare sequence variants may be important in understanding the biology of common diseases, but clearly establishing their association with disease is often difficult. Association studies of such variants are becoming increasingly common as large-scale sequence analysis of candidate genes has become...
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