Article
Genetic association signal near NTN4 in Tourette syndrome.
Annals of neurology - 1 Aug 2014
Paschou Peristera, Yu Dongmei, Gerber Gloria, Evans Patrick, Tsetsos Fotis, Davis Lea K, Karagiannidis Iordanis, Chaponis Jonathan, Gamazon Eric, Mueller-Vahl Kirsten, Stuhrmann Manfred, Schloegelhofer Monika, Stamenkovic Mara, Hebebrand Johannes, Noethen Markus, Nagy Peter, Barta Csaba, Tarnok Zsanett, Rizzo Renata, Depienne Christel, Worbe Yulia, Hartmann Andreas, Cath Danielle C, Budman Cathy L, Sandor Paul, Barr Cathy, Wolanczyk Thomas, Singer Harvey, Chou I-Ching, Grados Marco, Posthuma Danielle, Rouleau Guy A, Aschauer Harald, Freimer Nelson B, Pauls David L, Cox Nancy J, Mathews Carol A, Scharf Jeremiah M
Abstract excerpt
Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10(-3) ) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry-matched controls. Only rs2060546 on chromosome 12q22 (p = 3.3 × 10(-4) ) remained significant after Bonferroni correction....
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