Article
Association of Rare Genetic Variants in Opioid Receptors with Tourette Syndrome.
Tremor and other hyperkinetic movements (New York, N.Y.) - 1 Jan 2019
Depienne Christel, Ciura Sorana, Trouillard Oriane, Bouteiller Delphine, Leitão Elsa, Nava Caroline, Keren Boris, Marie Yannick, Guegan Justine, Forlani Sylvie, Brice Alexis, Anheim Mathieu, Agid Yves, Krack Paul, Damier Philippe, Viallet François, Houeto Jean-Luc, Durif Franck, Vidailhet Marie, Worbe Yulia, Roze Emmanuel, Kabashi Edor, Hartmann Andreas
Abstract excerpt
Background: Genes involved in Tourette syndrome (TS) remain largely unknown. We aimed to identify genetic factors contributing to TS in a French cohort of 120 individuals using a combination of hypothesis-driven and exome-sequencing approaches. Methods: We first sequenced exons of SLITRK1-6 and HDC in the TS cohort and subsequently sequenced the exome of 12 individuals harboring rare variants in these genes to...
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