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Article

Integrin αv expression is required for the acquisition of a metastatic stem/progenitor cell phenotype in human prostate cancer.

The American journal of pathology - 1 Nov 2011

van den Hoogen Christel, van der Horst Geertje, Cheung Henry, Buijs Jeroen T, Pelger Rob C M, van der Pluijm Gabri

Abstract excerpt

Integrins participate in multiple cellular processes, including cell adhesion, migration, proliferation, survival, and the activation of growth factor receptors. Recent studies have shown that expression of αv integrins is elevated in the prostate cancer stem/progenitor cell subpopulation compared with more differentiated, committed precursors. Here, we examine the functional role of αv integrin receptor...

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Identifiers

PMID: 21907176
DOI: 10.1016/j.ajpath.2011.07.011
PMCID: PMC3204028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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