Article
Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence.
Drug and alcohol dependence - 1 Apr 2009
Kuo Po-Hsiu, Kalsi Gursharan, Prescott Carol A, Hodgkinson Colin A, Goldman David, Alexander Jeffry, van den Oord Edwin J, Chen Xiangning, Sullivan Patrick F, Patterson Diana G, Walsh Dermot, Kendler Kenneth S, Riley Brien P
Abstract excerpt
BACKGROUND: The relation of gamma-aminobutyric acid (GABA) to alcohol dependence (AD) has been widely studied. Several previous studies suggest that GABA may be involved in alcohol withdrawal, tolerance, and the symptoms that form an AD diagnosis. The genes coding for glutamate decarboxylase (GAD), the rate-limiting enzyme in GABA synthesis, are of potential interest for their association to ethanol consumption...
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