Article
Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma.
Journal of neuropathology and experimental neurology - 1 Jan 1995
Kraus J A, Koopmann J, Kaskel P, Maintz D, Brandner S, Schramm J, Louis D N, Wiestler O D, von Deimling A
Abstract excerpt
Loss of heterozygosity (LOH) in specific chromosomal regions, which are likely to harbor tumor suppressor genes, has been associated with human gliomas. In this study we have analyzed astrocytic and oligodendroglial tumors for LOH on chromosomes 1 and 19. By microsatellite analysis LOH was found...
Topics
- Alleles
- Astrocytes
- Cell Differentiation
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 19
- Glioma
- Heterozygote
- Humans
- Oligodendroglia
- Oligodendroglioma