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Article

Phenotype versus genotype correlation in oligodendrogliomas and low-grade diffuse astrocytomas.

Acta neuropathologica - 1 Mar 2002

Watanabe Takao, Nakamura Mitsutoshi, Kros Johan M, Burkhard Christoph, Yonekawa Yasuhiro, Kleihues Paul, Ohgaki Hiroko

Abstract excerpt

Oligodendrogliomas typically show loss of heterozygosity (LOH) on chromosomes 1p and 19q, which correlates with their response to chemotherapy, whereas low-grade astrocytomas are characterized by frequent TP53 mutations and lack of sensitivity to alkylating therapeutic agents. Unequivocal histological distinction of low-grade diffuse astrocytomas from oligodendrogliomas and oligoastrocytomas is often difficult....

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Identifiers

PMID: 11907807
DOI: 10.1007/s004010100464

Genes

MGMT

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