Article
Correlation of histology and molecular genetic analysis of 1p, 19q, 10q, TP53, EGFR, CDK4, and CDKN2A in 91 astrocytic and oligodendroglial tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2002
Ueki Keisuke, Nishikawa Ryo, Nakazato Yoichi, Hirose Takanori, Hirato Junko, Funada Nobuaki, Fujimaki Takamitsu, Hojo Shuntaro, Kubo Osami, Ide Takafumi, Usui Masaaki, Ochiai Chikayuki, Ito Shoichi, Takahashi Hiroshi, Mukasa Akitake, Asai Akio, Kirino Takaaki
Abstract excerpt
PURPOSE: The histological diagnosis of human gliomas is of great importance for estimating patient prognosis and guiding therapy but suffers from being subjective and, therefore, variable. We hypothesized that molecular genetic analysis could provide a more objective means to classify tumors and, thus, reduce diagnostic variability. EXPERIMENTAL DESIGN: We performed molecular genetic analysis on 91 nonselected...
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